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KMID : 0379520120280010033
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한국독성학회지
2012 Volume.28 No. 1 p.33 ~ p.38
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Methanolic Extract Isolated from Root of Lycoris aurea Inhibits Cancer Cell Growth and Endothelial Cell Tube Formation In Vitro
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Kang Moo-Rim
Lee Chang-Woo
Yun Ji-Eun
Oh Soo-Jin
Park Song-Kyu
Lee Ki-Ho
Kim Hwan-Mook
Han Sang-Bae
Kim Hyoung-Chin
Kang Jong-Soon
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Abstract
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In this study, we investigated the effect of methanolic extract isolated from the root of Lycoris aurea (LA) on the growth of cancer cells and the tube formation activity of endothelial cells. Various cancer cells were treated with LA at doses of 0.3, 1, 3, 10 or 30 μg/ml and LA significantly suppressed the growth of several cancer cell lines, including ACHN, HCT-15, K-562, MCF-7, PC-3 and SK-OV-3, in a dose-dependent manner. We also found that LA induced cell cycle arrest at G2/M phase in ACHN renal cell adenocarcinoma cells. Further study demonstrated that LA concentration-dependently inhibited the tube formation, which is a widely used in vitro model of reorganization stage of angiogenesis, in human umbilical vein endothelial cells. Collectively, these results show that LA inhibits the growth of cancer cells and tube formation of endothelial cells and the growth-inhibitory effect of LA might be mediated, at least in part, by blocking cell cycle progression.
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KEYWORD
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Lycoris aurea, Cancer, Growth, Cell cycle, Tube formation
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